What is RegenPRP™?
RegenPRP™ is safe and effective, rapidly preapred at point of care with RegenKit® Medical Devices, rich in nutrients and growth factors to restore and revitalize tissues at a cellular level, and autologous: “Made FROM You FOR You!”™
Platelet-Rich Plasma
Platelets are key factors in tissue repair mechanisms.1 They provide essential growth factors, such as FGF, PDGF, TGF-β, EGF, VEGF, IGF, which are involved in stem cell migration, differentiation and proliferation. Platelets also stimulate fibroblasts and endothelial cells to induce the deposition of new extracellular matrix and neovascularization, respectively. These cell fragments (platelets are fragments of megakaryocytes) essentially act as a conductor to facilitate a highly-orchestrated and multi-lateral engagement of the body’s natural healing mechanisms. The platelets prepared in RegenPRP™ are concentrated from the patient’s own blood.
Plasma
Plasma is the liquid matrix which sustains and facilitates the passage of cellular elements and nutrients throughout the body, sustaining the health and vigor of tissues. It contains many factors essential for cell survival including nutrients, vitamins, hormones, electrolytes, growth factors (such as IGF and HGF), and proteins. Among the plasma proteins, the molecules vital for the coagulation process and for formation of the fibrin polymer will serve as a scaffold for cell migration and new tissue generation.
Platelet-Rich Plasma
Platelet-Rich Plasma is a preparation borne from the collection of whole blood and separation of its components in such a way that the plasma, platelets, nutrients and growth factors are isolated from the Granulocytes (GRN) and Red Blood Cells (RBC). In some cases, a significant recovery of Mononuclear Cells (MNC) may be desirable. Therefore it is important to differentiate between the two subdivisions of White Blood Cells (WBC)
RegenPRP™ | Methodology
STANDARDIZED AUTOLOGOUS PREPARATION
With the ability to rapidly generate fresh autologous preparations at point of care, cellular components are selectively isolated in a manner which not only serves to maximize their biocompatibility, but also their bioactivity. This allows Platelets, and their supporting elements, to maintain their function whilst being concentrated in a manner which ensures the utmost standard of purity, thanks to what we have termed as the “GMP Lab in a Tube.”
ACADEMIC COLLABORATION
RegenLab® works closely with leading experts around the globe in order to assess and refine approaches with the goal of revolutionizing approaches toward regenerative medicine and improving quality of life for the patient.
Our academic partnerships represent a key component of our mission, to further initiatives of both public health and patient welfare.
CLINICAL EXPLORATION
With Platelets already having a proven role in the healing of tissues (e.g. as key components in migration, proliferation and differentiation), the importance of further study in this regard is paramount in our initiatives.
With over 200 publications worldwide, and 4 textbooks published in collaboration with the BioBridge Foundation and our academic partners, RegenLab® prides itself as a leader of clinical advancement in the field of Regenerative Medicine.
PERSISTENT INNOVATION
With this methodology comes a persistent need to raise the bar, innovating new technological approaches to further develop the fields of Cell Therapy &; Tissue Engineering.
RegenKit® Medical Device Kits represent just the beginning, with a significant portfolio of RegenLab® technology under investigative status and pending FDA Clearance or Approval.
Technological benefits
- Standardized preparation
- Minimum Blood Requirements
- Closed-Loop System: maximized safety
- Stable Physical Separation
- Reversible, Pharmaceutical-Grade Anticoagulation
- pH Neutral Anticoagulant for Patient Tolerability
- Rapid Centrifugation: 5 minutes
- Ease of Preparation: efficient & reproducible
- Facilitates and streamlines routine practice
Biological benefits
- Standardized, Leukocyte-Poor, and Consistent
- Platelet Recovery >80%
- High Platelet Quality: viability & functionality
- Full Plasma Recovery: maximized Growth factor and fibrinogen content
- Maximized Purity: >99.7% RBC depletion
- Extreme Cellular Selectivity: ~96.5% GRN & 70-80% MNC elimination
Scientific benefits
- Demonstrated safety and efficacy
- Evidence-based outcomes for numerous therapeutic indications
- Large number of clinical studies, with over 200 publications